NFL Early Look: Week 1 Odds And Totals

By Roy Burton   June 9, 2022 

NFL Early Look: Week 1 Odds And Totals


Last month, the NFL released its entire 18-week schedule for the 2022 season. Bettors and sportsbooks alike looked closely at the matchups and soon, actionable NFL odds appeared for these contests. The league will open the regular season with a potential Super Bowl preview, and finish Week 1 with a high-profile matchup on Monday Night. 

Oddsmakers at the different sportsbooks remain sharp when setting spreads and totals for NFL games. But Week 1 often provides bettors with solid potential payouts considering the uncertainty of the new season. Following an offseason flurry of activity, NFL Futures bets hint at the favorites for the season. But those plays remain unclear until the games actually start. 

The NFL’s 2022 Week 1 slate sees all 16 teams take the field. Six divisional rivals square off in their first game of the season. Fans eagerly await the debuts of their team’s newest additions, with many hoping solid Super Bowl odds heading into the season equals potential success in 2022. 

Here’s a look at the odds and totals for each NFL Week 1 contest to start the 2022 season. 

2022 NFL Week 1 Odds and Totals

Buffalo Bills at Los Angeles Rams

  Spread Total Moneyline
Bills Best Odds    -1/-103 (UniBet)   U 52/-109 (UniBet)   +100 (BetMGM)
Rams Best Odds    +1/-115 (FanDuel)   O 52/-110 (DraftKings)   -106 (FanDuel)

The NFL opens its season with the defending Super Bowl champs squaring off with the odds-on Super Bowl favorite for 2022. These two high-octane offenses should provide a show to open the NFL’s new season. The 52-point total stands tied for the second-highest total of Week 1. 

New England Patriots at Miami Dolphins

When: Sunday, September 11th, 1:00 PM

Where: Hard Rock Stadium, Miami Gardens, FL

  Spread Total Moneyline
Patriots Best Odds    +2.5/-109 (UniBet)   U 44.5/-105 (PointsBet)   +130 (DraftKings)
Dolphins Best Odds    -2.5/-110 (BetMGM)   O 44.5/-110 (FanDuel)   -145 (BetMGM)

These two AFC East rivals opened the 2021 season versus one another, and will do so again in 2022. This time, the Patriots travel to South Florida for the season opener as underdogs. There are high expectations in Miami following an offseason of change for the Dolphins. This Week 1 matchup against Bill Belichick and Co should provide a solid measuring stick for Miami.

Jacksonville Jaguars at Washington Commanders

When: Sunday, September 11th, 1:00 PM

Where: FedExField, Landover, MD

  Spread Total Moneyline
Jaguars Best Odds    +3.5/-109 (UniBet)   U 44.5/-110 (DraftKings)   +175 (Caesars)
Commanders Best Odds    -3.5/-110 (BetMGM)   O 44.5/-102 (UniBet)   -189 (BetMGM)

Both of these teams usher in new eras to start 2022. The Jaguars turned over the coaching staff, bringing in former Eagles head coach Doug Peterson to help make Jacksonville a contender with Trevor Lawrence entering his second season. Meanwhile, Washington adopted their new nickname, the Commanders, and hope for a playoff run following a disappointing 2021 campaign with a new quarterback, Carson Wentz, at the helm.

Baltimore Ravens at New York Jets

When: Sunday, September 11th, 1:00 PM

Where: MetLife Stadium, East Rutherford, NJ

  Spread Total Moneyline
Ravens Best Odds    -4.5/-110 (BetMGM)   U 45.5/-110 (BetMGM)   -196 (DraftKings)
Jets Best Odds    +4.5/-110 (BetMGM)   O 45.5/-104 (UniBet)   +200 (FanDuel)

The Ravens ended their 2021 season on a six-game losing skid. Baltimore hopes to make another run to the postseason now that they’ve had an offseason to heal. The Jets, meanwhile, enter the 2022 season with a great deal of hope following Zach Wilson’s rookie year and after loading up in the NFL Draft. 

New Orleans Saints at Atlanta Falcons

When: Sunday, September 11th, 1:00 PM

Where: Mercedes-Benz Stadium, Atlanta, GA

  Spread Total Moneyline
Saints Best Odds    -4/-110 (BetMGM)   U 42.5/-110 (BetMGM)   -189 (DraftKings)
Falcons Best Odds    +4/-110 (BetMGM)   O 42.5/-110 (BetMGM)   +172 (FanDuel)

This matchup pits two NFC South rivals headed in opposite directions. The Saints hope for a bounce back year under a new head coach and with a healthy Jameis Winston under center. The Falcons, meanwhile, traded away their franchise quarterback and pivoted to a rebuild for the 2022 season. 

Cleveland Browns at Carolina Panthers

When: Sunday, September 11th, 1:00 PM

Where: Bank of America Stadium, Charlotte, NC

  Spread Total Moneyline
Browns Best Odds     -3.5/-110 (BetMGM)   U 42.5/-110 (BetMGM)   -175 (BetMGM)
Panthers Best Odds     +3.5/-110 (BetMGM)   O 42.5/-110 (BetMGM)   +160 (DraftKings)

While both of these clubs were in the Deshaun Watson sweepstakes this offseason, only one of them came away with the Pro Bowl quarterback. Watson’s availability remains in question amid potential league suspension, but the Panthers have questions at the quarterback position as well. 

San Francisco 49ers at Chicago Bears

San Francisco 49ers defensive end Samson Ebukam (56) sacks Chicago Bears quarterback Justin Fields (1) during the second half at Soldier Field. Mike Dinovo-USA TODAY Sports

When: Sunday, September 11th, 1:00 PM

Where: Soldier Field, Chicago, IL

  Spread Total Moneyline
49ers Best Odds     -6.5/-110 (BetMGM)   U 42/-105 (PointsBet)   -270 (FanDuel)
Bears Best Odds     +6.5/-109 (UniBet)   O 42/-110 (FanDuel)   +230 (UniBet)

This classic NFC rivalry resumes in 2022 with San Francisco coming off a conference championship game appearance. The Bears welcome in a new head coach hoping to see a leap from Justin Fields in his second season. This came could pit two top-five quarterbacks from the 2021 class against one another if Trey Lance takes over for the Niners in 2022. 

Pittsburgh Steelers at Cincinnati Bengals

When: Sunday, September 11th, 1:00 PM

Where: Paul Brown Stadium, Cincinnati, OH

  Spread Total Moneyline
Steelers Best Odds     +6.5/-109 (UniBet)   U 44.5/-110 (BetMGM)   +225 (BetMGM)
Bengals Best Odds   -6.5/-110 (DraftKings)   O 44.5/-110 (BetMGM)   -238 (FanDuel)

The defending AFC Champions host their AFC North division rivals to start the 2022 season. Following an electric run to the Super Bowl last season, the Bengals hope to build on those successes around Joe Burrow. Meanwhile, the Steelers will have a new starting quarterback following the retirement of Ben Roethlisberger. Whether that’s Mitchell Trubisky or rookie Kenny Pickett remains to be seen. 

Philadelphia Eagles at Detroit Lions

When: Sunday, September 11th, 1:00 PM

Where: Ford Field, Detroit, MI

  Spread Total Moneyline
Eagles Best Odds     -4/-108 (UniBet)   U 46.5/-110 (BetMGM)   -189 (BetMGM)
Lions Best Odds     +4/-110 (DraftKings)   O 46.5/-110 (BetMGM)   +175 (Caesars)

The Eagles enter the 2022 season looking to build on their run to the playoffs last year. Meanwhile, the Lions look to further improve under head coach Dan Campbell. Despite finishing with the league’s second-worst record, Detroit ended 2021 with the fourth-best mark against the spread.  

Indianapolis Colts at Houston Texans

When: Sunday, September 11th, 1:00 PM

Where: NRG Stadium, Houston, TX

  Spread Total Moneyline
Colts Best Odds       -7.5/-110 (BetMGM)     U 44.5/-105 (PointsBet)       -357 (UniBet)  
Texans Best Odds       +7.5/-105 (DraftKings)     O 44.5/-102 (UniBet)       +300 (Caesars)

The Colts took a crushing Week 18 lost last season and missed the playoffs. As a result, Indy turns to yet another starting quarterback for the new season, this time bringing in former Falcons signal caller Matt Ryan. The Texans finally traded away Deshaun Watson, so now the team can look to rebuild around Davis Mills. This AFC South matchup sports the only Week 1 odds spread greater than a touchdown. 


Kansas City Chiefs at Arizona Cardinals

Cardinals quarterback Kyler Murray looks to the sideline after failing to convert a third down during the first half of the preseason game against the Chiefs at State Farm Stadium in Glendale on August 20, 2021. David Wallace/The Republic via Imagn Content Services, LLC

When: Sunday, September 11th, 4:25 PM

Where: State Farm Stadium, Glendale, AZ

  Spread Total Moneyline
Chiefs Best Odds     -3/-110 (BetMGM)   U 53/-110 (DraftKings)   -149 (DraftKings)
Cardinals Best Odds     +3/-105 (DraftKings)   O 53/-110 (DraftKings)   +140 (Caesars)

This matchup of high-octane offenses sports the highest point total for the early Week 1 odds. The Chiefs come to this one after a disappointing loss in the AFC title game, while the Cardinals took a tough playoff loss of their own. Time will tell if KC did enough to replace electric receiver Tyreek Hill, who they traded to Miami this offseason. 

Las Vegas Raiders at Los Angeles Chargers

When: Sunday, September 11th, 4:25 PM

Where: SoFi Stadium, Inglewood, CA

  Spread Total Moneyline
Raiders Best Odds   +4/-110 (BetMGM)   U 52/-110 (DraftKings)   +160 (FanDuel)
Chargers Best Odds   -4/-109 (UniBet)   O 52/-15 (PointsBet)   -179 (DraftKings)

These AFC West clubs resume their rivalry in Week 1 following a Week 18 contest last season that saw the Raiders knock the Chargers out of the playoff picture. Los Angeles made major additions to their defense for 2022 in hopes of keeping pace with their high-octane offense. The Raiders made meaningful additions of their own, most notably Davante Adams. 

Green Bay Packers at Minnesota Vikings

When: Sunday, September 11th, 4:25 PM

Where: U.S. Bank Stadium, Minneapolis, MN

  Spread Total Moneyline
Packers Best Odds     -1.5/-110 (BetMGM)   U 49/-110 (DraftKings)   -120 (BetMGM)
Vikings Best Odds    +1.5/-110 (BetMGM)   O 49/-110 (DraftKings)   +105 (Caesars)

The Green Bay Packers welcomed by Aaron Rodgers but lost his favorite target this offseason. Whether or not the Packer did enough to replace Davante Adams remains to be seen, which likely is the reason why this spread remains nearly a pick-‘em at this point. The Vikings hope a new head coach will make the difference for Kirk Cousins and Co in this NFC North matchup. The 49-point opening total points toward a shootout, but that could be a stretch for these clubs in 2022. 

New York Giants at Tennessee Titans

When: Sunday, September 11th, 4:25 PM

Where: Nissan Stadium, Nashville, TN

  Spread Total Moneyline
Giants Best Odds     +6.5/+100 (DraftKings)   U 44.5/-115 (BetMGM)   +140 (BetMGM)
Titans Best Odds   -6.5/105 (FanDuel)   O 44.5/103 (UniBet)   -278 (FanDuel)

This interconference contest pits a pair of teams moving in opposite directions in the futures markets. The Giants remain hopeful for 2022 following the hiring of Brian Daboll as head coach and the return of Daniel Jones at quarterback. The Titans, meanwhile, hope a returning Derrick Henry can offset the loss of top receivers A.J. Brown and Julio Jones. The near-touchdown spread may be too much for Tennessee following this offseason. 

Tampa Bay Buccaneers at Dallas Cowboys

When: Sunday, September 11th, 8:20 PM

Where: AT&T Stadium, Arlington, TX

  Spread Total Moneyline
Buccaneers Best Odds     -2.5/-108 (UniBet)   U 52/-110 (BetMGM)   -132 (FanDuel)
Cowboys Best Odds   +2.5/-110 (BetMGM)   O 52/-105 (PointsBet)   +115 (DraftKings)

These two clubs squared off to start the 2021 season with Dallas nearly stealing an upset victory. The Bucs happily welcomed back Tom Brady following his brief retirement this offseason and look to make another push to the Super Bowl. The Cowboys hope to overcome their recent postseason failings. The 52-point opening total stands as tied for the second-highest total for Week 1, and considering these offenses, the Over isn’t out of the question. 

Denver Broncos at Seattle Seahawks

When: Monday, September 12th, 8:15 PM

Where: Lumen Field, Seattle, WA

  Spread Total Moneyline
Broncos Best Odds     -4.5/-105 (PointsBet)   U 41.5/-110 (BetMGM)   -179 (Caesars)
Seahawks Best Odds     +4.5/105 (BetMGM)   O 41.5/-103 (UniBet)   +172 (FanDuel)

The NFL Week 1 slate closes with a marquee matchup on Monday Night. Following their blockbuster trade this offseason, Denver visits the Seahawks in Russell Wilson’s return to Seattle in his first game as a Bronco. The opening point total for this one indicates a defensive struggle, which tracks with the Seahawks rebuilding offense. Wilson could very well lead a rout in this one. 

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