This will go a long way in deciding the AFC South winner, as these two teams come into this game tied for first place and meet twice in the final three weeks of the regular season. The dynamic of the division changed last week when Denver went into Houston as a nine-point underdog and blew out the Texans, while Tennessee kept rolling with a 42-21 win in Oakland. The Titans are 5-1 since turning to Ryan Tannehill over Marcus Mariota at quarterback, but a major reason for Tennessee’s turnaround has been running back Derrick Henry. The former Heisman Trophy winner has rushed for over 100 yards in each of the last four games, and he is now second in the NFL in total rushing yards. Both teams are evenly matched on offense, as they each average around 24 points per game. The Titans have an edge on defense, allowing 19.6 points per game compared to Houston’s 23.8. Trends here heavily favor the Titans. Tennessee is riding a three-game home winning streak over Houston, and Tannehill is also 3-0-1 against the spread at home since taking over as starting QB. Houston is 3-6 both straight up and ATS against AFC South opponents on the road and 0-4-1 ATS in December road games since 2017.